CAAPA Pathogenic Variant Annotation

I am a member of the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA), a collaborative effort to study genetic variation and its role in health among populations of African descent across the Americas. One of my projects within CAAPA is CAAPAWEB, an interactive platform designed to make allele frequencies, local ancestry, and functional annotations accessible to researchers and students. With CAAPAWEB, you can explore population-specific allele frequencies, ancestry-stratified patterns in admixed groups, and measures of genetic differentiation (FST) through dynamic visualizations.

Key Findings & Visualizations

1. SNP search interface

Search for any SNP across the genome and instantly pull up population-level frequencies and functional annotations.

2. Allele frequency barplots for populations

Compare allele frequencies across over 60 human populations in one view.

3. FST matrix heatmap

Visualize population differentiation with interactive FST heatmaps.